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and the PEGylated agonist NLY01, which on this account does not effectively reach the brain despite being engineered for penetrance, was negative in a Phase 2 Parkinsons trial [12,13]

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This work is supported by the Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (Grant number: 24HHZYSS00007)

EC 50 and E max values for each curve were calculated by Prism 8.0 software

these residual ROS levels are sufficient to perturb metabolism and contribute to cell death alongside other mechanisms