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Despite the immunosuppressive microenvironment of lymphangiogenic tumors mediated in part by LEC antigen presentation-induced T cell tolerance (94, 95, 98), they are more sensitive to systemic immunotherapy due to the elevation of CCL21 in LECs, which promotes the retention of nave T cells and DCs in lymphangiogenic tumors via CCL21/CCR7 chemokine axis (100)

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To make the best decision about which peptide is the best candidate for further research, researchers should adopt a cautious approach and consider long-term follow-up for research subjects

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