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Additionally, changes in subchondral bone contribute to cartilage destruction, primarily through an imbalance between osteoblastic and osteoclastic activity (Hu Y et al., 2021)
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While most of the 7.4 million individuals living with clinical Alzheimer's dementia and the estimated 4.2 million Americans with MCI due to Alzheimer's are 65 and older, research shows that physiological changes marking the earliest stages of Alzheimer's disease can begin up to 20 years before measurable cognitive impairment