These GI side effects are the main reason for the slow initial dosing jumping straight to a full dose would cause much more nausea
10.1038/nrneurol.2016.77 368 Wood-AllumC
The primary mechanism involves binding to receptors in the pancreas, brain, and gastrointestinal tract
Units to draw = (desired dose in mg / concentration in mg per mL) x 100 That is the entire formula

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Curcumin attenuates testicular injury in rats with streptozotocin-induced diabetes