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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 1% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

First isolated from human plasma in 1973, this naturally occurring tripeptide has since been shown to influence thousands of genes involved in tissue repair, inflammation control, and matrix remodeling

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Generally, mitochondrial respiration control, including oxygen consumption rate (OCR) and respiratory control ratio (RCR), is utilized to measure the mitochondrial function in diverse cell populations (Lebiedzinska et al., 2010

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