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The TECOS trial showed no difference between the placebo and a sitagliptin group (Table 2) [47,48,49]

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Instead, we used DM-2OG treatment to increase the cellular 2-OG pool as a surrogate for blocking the OGDHc

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Factors influencing this include dosage, adherence to treatment, lifestyle modifications, and baseline body weight

GIP-1s and GIPs are not appropriate for pregnant women and individuals with severe gastrointestinal conditions such as gastroparesis and inflammatory bowel disease