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Protective role of glucagon-like peptide-1 against glucosamine-induced cytotoxicity in pancreatic beta cells

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A two-year carcinogenicity study was conducted in Sprague-Dawley rats with doses of 0.04, 0.2, and 0.5 mg/kg/day of pramlintide (3, 9, and 25 times the exposure resulting from the human dose of 360 mcg/day based on AUC, respectively)

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Human thyroid tissue expresses GLP-1 receptors at much lower levels than rodent tissue, with expression not exceeding 30% of human thyrocytes and parafollicular C-cells

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