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(ref) Seiwerth S, Milavic M, Vukojevic J, Gojkovic S, Krezic I, Vuletic LB, Pavlov KH, Petrovic A, Sikiric S, Vranes H, Prtoric A, Zizek H, Durasin T, Dobric I, Staresinic M, Strbe S, Knezevic M, Sola M, Kokot A, Sever M, Lovric E, Skrtic A, Blagaic AB, Sikiric P

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In individuals with type 2 diabetes, we observed that metformin (850 mg) ingested 30 min before an intraduodenal glucose infusion of 8.37 kJ/min (2 kcal/min) reduced the rate of glucose absorption by approximately 10%, and that the augmentation of GLP-1 secretion by metformin was related directly to the magnitude of inhibition of glucose absorption [9]

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The Alpha-Cell as Target for Type 2 Diabetes Therapy