10.1038/sj.ijo.0803040 267
PMID: 32695209
The most common side effects of GLP-1s may include: nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, gas, stomach flu, and heartburn
And finally, GLP-1 slows gastric emptying , prolonging the feeling of fullness until the next meal
Gaucher disease is a rare autosomal recessive genetic disease that is caused by the excessive accumulation of glucose neuraminidase in macrophages because of the dysfunction and abnormal lysosomal transport of glucosaminidase 123
This analgesic effect observed in vivo is likely underlain by liraglutides concerted anti-inflammatory action, as demonstrated in vivo in a mouse model of MIA, whereby liraglutide improves synovitis severity score, and also in vitro , whereby liraglutide dose-dependently decreased PGE 2, nitric oxide (NO), and IL-6 secretion, along with iNos , Cox2 , and Tnf- gene expression levels in both chondrocytes and macrophages