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The blocking of the lysosomal iron translocation of CSCs by inhibiting the divalent metal transporter 1 (DMT1) leads to iron accumulation and cell death with features of ferroptosis (Turcu et al., 2020)

Allopurinol is the first-line ULT, typically started at 100mg daily and titrated to achieve target serum uric acid levels below 360 mol/L (or below 300 mol/L in people with tophi)

Studies show that glutathione supplementation increases plasma antioxidant capacity and reduces oxidative stress biomarkers by up to 35%, confirming its role in recycling and regeneration pathways (NIH)

What About Microdosing GLP-1 Medications

The one combination to be careful about is using both on the same evening if your skin is already reactive

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