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Liver regulates lipid uptake, storage, release and homeostasis

Adequate protein intake and resistance exercise during treatment are important countermeasures

Based on these pre-clinical findings, a lead candidate, SAR425899 with similar receptor potencies was taken forward in Phase 1 and Phase 2 trials (see below)

Diabetologia 65(1):206215 Wei Y, Richardson TG, Zhan Y, Carlsson S (2023) Childhood adiposity and novel subtypes of adult-onset diabetes: a Mendelian randomisation and genome-wide genetic correlation study

The microscopic scores of liver and kidney tissues were calculated as the total of the scores given to each criterion

(2016) Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia, Oncotarget , 7 , 14659-14672, doi: Njlsson, R., and Norgren, S