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NICE guidelines recommend psychological interventions as first-line treatment for binge eating disorder, with pharmacological options considered only when psychological therapies have been ineffective or declined

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They help curb appetite, slow gastric emptying, and reduce postprandial glucose spikes. Youve likely encountered names such as semaglutide (Ozempic, Wegovy, Rybelsus), tirzepatide (Mounjaro, Zepbound), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda). Early versions of these drugs required daily injection

Another oral alpha-synuclein aggregation inhibitor, Anle138b [112], showed favourable safety and pharmacokinetics in a phase 1 trial (NCT04208152) [113]

The secretion and release of HMGB1 is not only regulated by post-translational modification, but also promoted by ferroptosis 31

The key to weight loss is to adopt a balanced diet and regular exercise, whether you take berberine or not