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In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)

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Mathew B, Amaechi C, Asante K, Albuquerque E, Benedict A, Kneeream E, Lopez L, et al

Author disclosures: JWM has been a consultant to Church & Dwight Co., Inc