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In summary, obesity leads to decreased mitochondrial function and increased insulin resistance

Liu et al., 2017

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Contraindications L-carnitine is not recommended or requires medical advice in the following situations: Severe chronic kidney disease (accumulated TMAO) Unbalanced hypothyroidism (possible interference) Epilepsy : neurological advice necessary (varies by case) Pregnant or nursing women : as a precaution, insufficient data Children : except for specific medical prescription Known allergy to one of the components Drug interactions Seek medical advice before supplementation if you are taking: Anticoagulants (warfarin, AVK) : L-carnitine may potentiate anticoagulant effect INR monitoring Thyroid hormones (levothyroxine): possible interaction Antiepileptic drugs (valproic acid): to be discussed with your neurologist Chemotherapy : oncology consultation essential In case of serious chronic disease or regular medication use, consult your doctor before starting a course