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Andreassen and colleagues (J Med Chem, 2021) reported a design campaign that combined sequence substitutions to suppress fibrillation with a fatty-acid acylation that promotes albumin binding, yielding a molecule with a much longer reported plasma half-life in their preclinical models

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Chemistry & Structural Modification The peptide backbone has sequence Gly-His-Lys (one-letter GHK ) and is a 3-residue tripeptide

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