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As a microvascular complication of diabetes, the characteristic lesions of DKD include thickening of the basement membrane of renal capillaries and vascular damage, resulting in reduced blood flow and oxygen delivery to the kidneys

Patients were withdrawn if they experienced sustained elevations in blood pressure beyond predefined thresholds or significant increases from baseline [2]

Hambright WS, Fonseca RS, Chen L, Na R, Ran Q (2017) Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

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