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Contraindications: Active uveal inflammation Most cases of angle-closure glaucoma , due to the possibility of increasing angle block Hypersensitivity to the active or inactive ingredients Side Effects: Retinal detachment has been reported in a few cases Stinging, burning, lacrimation Iris cysts may form Lens opacities Cardiac irregularities Pharmacokinetics: Administered in eye drops to patients with glaucoma ) Forms an irreversible covalent bond with the ACh binding site on cholinesterase (duration of action is ~100 hrs Drug Interactions: Potentiates other cholinesterase inhibitors such as succinylcholine or organophosphate and carbamate insecticides Patients undergoing systemic anticholinesterase treatment should be warned of the possible additive effects References: Merck Manual Professional Edition (2026): Medications Used to Treat Glaucoma
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10.1002/jor.22831 12 FuX.XuM.JiaC.XieW.WangL.KongD.et al (2016)
doi: 10.23736/S0391-1977.20.03268-X 98 XuXHendryxMLiangXKaheKLiYLuoJ
