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Tesamorelins visceral-fat effect rests on randomized, controlled human trials the top of the evidence hierarchy which is why it earned an FDA approval and a real prescribing label

The gut-blood barrier permeability - a new marker in cardiovascular and metabolic diseases

smaller or inconsistent effects outside this endophenotype

However, it also has been found to be associated with insulin resistance syndrome including obesity, fat distribution, hypertension, dyslipidemia, and cardiovascular disease [48]

Mechanistic Target: Studied for its interaction with MC1R (melanocortin 1 receptor) to attenuate NF-kB activation in experimental models

& Bassetti, M