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For those on a weight loss regimen with Wegovy and considering melatonin for sleep support, this question is particularly relevant

Wellberg Journal of Clinical Investigation.2025;[Epub] CrossRef Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan Dario Tuccinardi, Davide Masi, Mikiko Watanabe, Valeria Zanghi Buffi, Francesco De Domenico, Sabrina Berti, Valentina Cipriani, Melania Manco, Silvia Manfrini, Uberto Pagotto Journal of Endocrinological Investigation.2025

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have highlighted the occurrence of peripheral hypogonadism, a combination of central and peripheral forms, and pure hypothalamic deficit in some cases (206, 222)

However, larger, longer-term studies are necessary to confirm these effects

doi: 10.1007/s00405-019-05558-7, 37