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Retatrutide is an investigational medicine, not a routinely approved prescription treatment

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In summary, GLP-1R agonism decreases homeostatic and hedonic feeding, and modulates food intake not only via the hypothalamus and the hindbrain but also via signaling in the mesolimbic system, in which GLP-1R activation affects reward behavior and palatability

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Comment: A few commenters expressed their concern that the CMS proposal to no longer apply the Medical Home Model 50 eligible clinicians limit may limit participation in Advanced APMs by eligible clinicians in rural areas and those at small practices