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Another potential mechanism for age-dependent loss of antioxidant genes was provided by one of the studies showing that the presence of transcription repressor BACH1 along with the absence of coactivator CREB-binding protein (CBP) in the aged mice may convert NRF2 binding from an active ARE to an alternative ARE [114]

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Acknowledgements The authors declare that no specific funding or external assistance was received for this research, and no acknowledgements are made

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Five patients had no abnormalities and in two patients, collagen flowers were noted