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Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown

[PMC free article] [PubMed] [Google Scholar] 12.Atkinson GO, Davis PC, Patrick LE, Winn KJ, Ball TI, Wyly JB

More than 30 million Americans have type 2 diabetes, the most common form of diabetes

Orlistat improved cholesterol, blood pressure, and diabetes risk but caused gastrointestinal issues, sibutramine improved lipids, and rimonabant enhanced cardiovascular markers but increased mood disorder risk

Often used to reduce dark spots and hyperpigmentation

If nausea occurs, experiencing it during waking hours means you can manage it with movement, hydration, or food adjustments more easily than during sleep