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9,10,11 Advancing to Dual Therapy If monotherapy with the maximized dose of metformin fails to achieve the desired A1C goal within about 3 months, the following actions can be taken: (1) add a second oral agent, (2) add a glucagon-like peptide 1 (GLP-1) receptor agonist (injection), or (3) add basal insulin

Current evidence supports their safety for long-term use, but regular monitoring is advised

Arthroscopy 2015;31:2014-2020

Ecnoglutide is also approved in China as a treatment for Type II diabetes

The chart has to say it