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G protein-coupled receptors include an N-terminal extracellular domain (ECD) and a C-terminal transmembrane domain (TMD), linked to each other through a soft sequence

Heavy enough to challenge the muscle

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and b) Once activated (with its TM6 open), GLP-1R can activate the G as /AC/cAMP signaling axis robustly and continuously, hence the robust and prolonged cAMP signals GLP-1R (and GCGR) can produce