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caspase-8 can inhibit the kinase activity of RIPK1 and mediate its cleavage

48 Together with the diversity of ubiquitin linkage types, this architectural variability gives the UPS its extraordinary precision, enabling tight regulation of proteostasis and preventing the accumulation of toxic proteins under physiological and pathological stress

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Curr Opin Pediatr

Trost L, Watter DN, Carrier S, et al

These oxidative modifications can lead to the aggregation and dysfunction of these proteins, compromising the structural integrity of the sperms cytoskeleton and impairing motility