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The relevance of this observation extends to the wider family of GPCRs, with individual effects almost certainly receptor-specific, as both -arrestin-biased 54 and G protein-biased 55 ligands have proved effective for individual receptors in preclinical studies

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However, the intensity of appetite suppression may vary considerably between individuals

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While many patients experience benefits from taking GLP-1s, there are some fairly significant side effects associated with these medications

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