While the present study cannot distinguish between these mechanisms, the consistency of the finding and its sensitivity to dietary intervention suggest that coumarin may represent a diet-responsive marker of metabolic dysregulation in this population
In the future, in-depth analysis of the molecular mechanisms by which it induces gut microbiota dysbiosis (such as LPS release, activation of inflammatory signaling pathways, etc.) may offer a significant theoretical basis to support the development of OA therapeutic
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Early signs include fatigue and weakness, whilst neurological symptoms may appear later if deficiency remains untreated
