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Future Research Priorities in Safety and Tolerability Despite the promising role of GLP-1-based therapies, several areas require further investigation to ensure their long-term safety in adolescents: Long-Term Metabolic Effects: Future studies should evaluate how sustained GLP-1RA use affects insulin sensitivity, lipid metabolism, and cardiovascular health over decades

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Zheng D., Liwinski T., Elinav E

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10.1016/j.atherosclerosis.2009.10.012 [DOI] [PubMed] [Google Scholar] 17.Choi HD, Youn YK, Shin WG