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Clinical experience in patients with severe renal impairment is limited as there were only 5 patients with severe renal impairment (eGFR 15 to less than 30 mL/min/1.73 m2) exposed to lixisenatide in all controlled studies

Reduction of only a few essential SH-SH bonds in a biologic reactant can remarkably change its molecular properties

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The Joint Research Ethics Committee of St Jamess and Tallaght Hospitals approved the study and written informed consent was obtained from all participants

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