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Oxidation and Impurity Control Free glutathione can oxidize to GSSG, and polar GSH conjugates are often accompanied by excess starting material, hydrolysis products, and closely eluting byproducts

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When a supplement isn't absorbed properly, it can lead to two problems: you don't get the benefits you paid for, and the "waste" can cause side effects like digestive upset or skin reactions

doi:10.1016/j.freeradbiomed.2005.04.020

doi: 10.1007/s00415-021-10871-5 103 SansoneGMegevandPVullimozSCorbettaMPicardFSeeckM

doi:10.1016/j.cmet.2018.02.011 High-Dose Vitamin C IV: Collagen Synthesis and Photoprotection Intravenous vitamin C at 10-25g achieves plasma concentrations of 13,000-20,000 umol/L 70-100x higher than maximum oral absorption of 220 umol/L