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Given that glutaryllipoyl adducts form under conditions of glutarate excess on another TCA cycle ketoacid dehydrogenase, the PDHc 9 , we hypothesized that the major role of ABHD11 may be to reverse lipoyl glutarylation, maintaining TCA cycle integrity (Fig

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For example, although low-carbohydrate diets may promote weight loss and metabolic benefits (130), insufficient carbohydrate intake can reduce the abundance of butyrate-producing bacteria and fecal butyrate concentrations, potentially impairing gut and systemic immune homeostasis (131)

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