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This strategy has been applied to dulaglutide, where two GLP-1 molecules are fused to the Fc fragment of IgG4, increasing the half-life while reducing the renal elimination due to the increased molecular weight

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Brain slice studies have shown that exendin-4 can increase the firing rates of DMH neurons, enhancing the neurons sensitivity to a high-fat diet (HFD) compared to a control diet [72]

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