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The combination also converted inflammatory M1 macrophages into anti-inflammatory M2 macrophages by increasing IL-10 and Arg-1 levels, decreasing MCP1 and CXCL9 levels, and promoting T reg cell development via Foxp3 gene activation (259)

Preclinical data consistently show neuroprotective effects, though the dedicated EVOKE trial of semaglutide for Alzheimer's disease found no significant benefit

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Athletes and physically active individuals may potentially benefit from the wound healing and anti-inflammatory properties of these peptides in treating common sports-related injuries including muscle strains, tendon injuries, and ligament sprains

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