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Osteoporosis GLP-1 promotes osteoblast proliferation and differentiation while suppressing osteoclastogenesis via NF-B/MAPK inhibition and OPG/RANKL rebalancing

This transactivation of GPX1 by p53 links the p53 signalling pathway to the antioxidant pathway (38)

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Dichotomous outcomes were analyzed using RR and 95% CI calculated from fixed-effects models

As GLP-1R agonists mediate their appetite-reducing effects within the central nervous system, the trafficking phenotype of exendin-phe1 could result in reduced brain penetration, mitigating against presumed advantageous effects on neuronal GLP-1R desensitization