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Beyond the M2-polarization function, GLP-1R activation also supports macrophage migration, which may be mediated by its regulation of macrophage polarization and the effects of IL-6 [93, 94]
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This biological hunger can hit all at once, leading to a restart of the binge cycle even when on medication , or can come back with a vengeance when finishing weight loss medication , if binge eating patterns have not been addressed separately
Treatment should be discontinued if inadequate response occurs: less than 5% weight loss after 6 months for Wegovy or 12 weeks for Saxenda at maintenance doses
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