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Differences between the early and late relative activity of each mutational signature were assessed using a Wilcoxon signed-rank test, and P values were corrected across signatures using the BenjaminiHochberg procedure ( q value)

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Boston Ale The Sam Adams Boston Ale is a classic copper-colored American ale

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With some 300 million smokers, the country should be a prime market for e-cigarettes, but government plans to regulate vapor like tobacco have darkened the outlook